Therapeutic strategies to remodel immunologically cold tumors

Heterotransplantation of mouse tumors to immunologically paralyzed rats.

Modeling and Novel Therapeutic Strategies for Brain Tumors

Čančer, M. 2018. From Genes to Therapy. Modeling and Novel Therapeutic Strategies for Brain Tumors. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1409. 62 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-513-0183-9. Medulloblastoma is the most common malignant pediatric brain tumor and is molecularly divided into four subgroups – WNT, SHH, Group 3...

New molecular strategies to cure brain tumors.

Overall, malignant primary and metastatic brain tumors remain as lethal in the 1990s as they were in the 1970s. Just as the introduction of radiation therapy 2 decades ago added several months to survival time, numerous chemotherapeutic trials have demonstrated only limited efficacy. Fortunately, recent discoveries in molecular medicine have not only revolutionized our understanding of the even...

Developing senescence to remodel the embryo

Cellular senescence is an irreversible form of cell cycle arrest that has been linked to several pathological conditions. In particular, senescence can function as a tumor suppressor mechanism, but is also thought to contribute to organismal aging. Paradoxically however, through the secretion of various factors, collectively termed the senescence-associated secretory phenotype (SASP), senescent...

Delivery strategies to achieve therapeutic myocardial angiogenesis.

The use of recombinant genes or growth factors to enhance myocardial collateral blood vessel function may represent a new approach to the treatment of cardiovascular disease. Proof of concept has been demonstrated in animal models of myocardial ischemia, and clinical trials are underway. Currently, it is unknown which is the safest and most effective delivery strategy to induce clinically impor...